 |
 |
|
|
| 05.03.2022 | 03:00 | Mazatlán FC | - | Club Necaxa | 2:1 (2:1) | |
| 19:00 | Atlas Guadalajara | - | Club Tijuana | 6:1 (2:0) | ||
| 19:00 | Pumas UNAM | - | CF Pachuca | 1:0 (1:0) | ||
| 11.04.2022 | 02:00 | Club León | - | CF Monterrey | 1:6 (0:3) | |
| 12.04.2022 | 00:00 | Atlético San Luis | - | Puebla FC | 3:1 (0:0) | |
| 00:00 | Deportivo Toluca | - | Cruz Azul | 3:1 (1:0) | ||
| 00:00 | Deportivo Guadalajara | - | FC Juárez | 0:0 (0:0) | ||
| 02:00 | Santos Laguna | - | CF América | 0:3 (0:1) | ||
| 15.04.2022 | 04:00 | UANL Tigres | - | Gallos Blancos | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Monterrey | 9 | 9 | 0 | 0 | 34:6 | 28 | 27 |
| 2 |
|
CF América | 9 | 7 | 1 | 1 | 22:6 | 16 | 22 |
| 3 |
|
UANL Tigres | 9 | 6 | 3 | 0 | 19:7 | 12 | 21 |
| 4 |
|
Deportivo Guadalajara | 9 | 5 | 4 | 0 | 14:4 | 10 | 19 |
| 5 |
|
CF Pachuca | 9 | 5 | 1 | 3 | 15:10 | 5 | 16 |
| 6 |
|
Atlas Guadalajara | 9 | 3 | 4 | 2 | 14:15 | -1 | 13 |
| 7 |
|
Gallos Blancos | 9 | 3 | 3 | 3 | 8:12 | -4 | 12 |
| 8 |
|
Pumas UNAM | 9 | 3 | 2 | 4 | 10:10 | 0 | 11 |
| 9 |
|
Atlético San Luis | 9 | 2 | 5 | 2 | 11:12 | -1 | 11 |
| 10 |
|
Deportivo Toluca | 9 | 3 | 2 | 4 | 14:16 | -2 | 11 |
| 11 |
|
Cruz Azul | 9 | 2 | 3 | 4 | 9:13 | -4 | 9 |
| 12 |
|
Club Tijuana | 9 | 1 | 6 | 2 | 13:19 | -6 | 9 |
| 13 |
|
Club Necaxa | 9 | 2 | 3 | 4 | 8:15 | -7 | 9 |
| 14 |
|
Mazatlán FC | 9 | 2 | 2 | 5 | 8:17 | -9 | 8 |
| 15 |
|
Club León | 9 | 2 | 2 | 5 | 11:21 | -10 | 8 |
| 16 |
|
Puebla FC | 9 | 2 | 1 | 6 | 7:15 | -8 | 7 |
| 17 |
|
FC Juárez | 9 | 1 | 1 | 7 | 8:15 | -7 | 4 |
| 18 |
|
Santos Laguna | 9 | 1 | 1 | 7 | 4:16 | -12 | 4 |
| Play-offs |
