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| U | Deportivo Guadalajara | - | Santos Laguna | 2:1 | ||
| R | Santos Laguna | - | Deportivo Guadalajara | 2:0 | ||
| U: 30.11.2017 16:30 | R: 03.12.2017 16:00 | Winnaars: Santos Laguna | ||||
| U | Monarcas Morelia | - | Pumas UNAM | 0:1 | ||
| R | Pumas UNAM | - | Monarcas Morelia | 2:1 | ||
| U: 30.11.2017 17:00 | R: 03.12.2017 17:00 | Winnaars: Pumas UNAM | ||||
