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| 18.03.2016 | 20:00 | Sparta Rotterdam | - | Fortuna Sittard | 1:1 (1:0) | |
| 20:00 | RKC Waalwijk | - | FC Volendam | 2:1 (1:0) | ||
| 20:00 | FC Eindhoven | - | VVV-Venlo | 2:0 (2:0) | ||
| 20:00 | Go Ahead Eagles | - | TOP Oss | 5:0 (2:0) | ||
| 20:00 | FC Den Bosch | - | NAC Breda | 3:6 (2:3) | ||
| 20:00 | Jong Ajax | - | Jong PSV | 1:2 (0:0) | ||
| 20:00 | Telstar | - | FC Dordrecht | 3:0 (0:0) | ||
| 20:00 | Helmond Sport | - | Almere City FC | 0:2 (0:0) | ||
| 20.03.2016 | 14:30 | Achilles'29 | - | MVV Maastricht | 1:2 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sparta Rotterdam | 30 | 22 | 5 | 3 | 73:31 | 42 | 71 |
| 2 |
|
VVV-Venlo | 31 | 18 | 6 | 7 | 72:35 | 37 | 60 |
| 3 |
|
FC Eindhoven | 31 | 18 | 5 | 8 | 51:36 | 15 | 59 |
| 4 |
|
NAC Breda | 30 | 18 | 4 | 8 | 71:32 | 39 | 58 |
| 5 |
|
Go Ahead Eagles | 30 | 13 | 6 | 11 | 45:35 | 10 | 45 |
| 6 |
|
FC Emmen | 30 | 13 | 6 | 11 | 51:46 | 5 | 45 |
| 7 |
|
FC Volendam | 30 | 12 | 8 | 10 | 47:34 | 13 | 44 |
| 8 |
|
MVV Maastricht | 31 | 11 | 8 | 12 | 41:51 | -10 | 41 |
| 9 |
|
Jong Ajax | 30 | 10 | 9 | 11 | 50:51 | -1 | 39 |
| 10 |
|
Jong PSV | 30 | 10 | 9 | 11 | 42:53 | -11 | 39 |
| 11 |
|
Telstar | 31 | 10 | 7 | 14 | 49:51 | -2 | 37 |
| 12 |
|
Almere City FC | 30 | 10 | 7 | 13 | 50:59 | -9 | 37 |
| 13 |
|
Fortuna Sittard | 31 | 10 | 6 | 15 | 36:64 | -28 | 36 |
| 14 |
|
FC Den Bosch | 30 | 8 | 10 | 12 | 37:43 | -6 | 34 |
| 15 |
|
Achilles'29 | 30 | 9 | 7 | 14 | 36:50 | -14 | 34 |
| 16 |
|
FC Dordrecht | 31 | 9 | 6 | 16 | 37:57 | -20 | 33 |
| 17 |
|
Helmond Sport | 30 | 8 | 8 | 14 | 43:52 | -9 | 32 |
| 18 |
|
TOP Oss | 30 | 7 | 7 | 16 | 35:63 | -28 | 28 |
| 19 |
|
RKC Waalwijk | 30 | 6 | 8 | 16 | 34:57 | -23 | 26 |
| Promotie | |
| Play-offs | |
| Play-offs | |
| Play-offs |
