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| 11.12.2022 | 12:15 | Willem II | - | NAC Breda | 1:2 (1:0) | |
| 14:30 | Almere City FC | - | ADO Den Haag | 4:1 (1:1) | ||
| 14:30 | De Graafschap | - | FC Eindhoven | 1:2 (0:0) | ||
| 14:30 | Jong Ajax | - | Jong FC Utrecht | 1:2 (1:1) | ||
| 14:30 | Telstar | - | FC Den Bosch | 1:0 (0:0) | ||
| 14:30 | TOP Oss | - | FC Dordrecht | 0:1 (0:0) | ||
| 14:30 | VVV-Venlo | - | MVV Maastricht | 2:1 (0:0) | ||
| 14:30 | Roda JC Kerkrade | - | Heracles Almelo | 1:3 (1:1) | ||
| 12.12.2022 | 18:45 | Jong AZ Alkmaar | - | Jong PSV | 2:3 (2:3) | |
| 21:00 | PEC Zwolle | - | Helmond Sport | 1:0 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Heracles Almelo | 17 | 13 | 1 | 3 | 47:21 | 26 | 40 |
| 2 |
|
PEC Zwolle | 17 | 12 | 2 | 3 | 41:19 | 22 | 38 |
| 3 |
|
MVV Maastricht | 17 | 10 | 3 | 4 | 31:24 | 7 | 33 |
| 4 |
|
FC Eindhoven | 17 | 9 | 5 | 3 | 30:21 | 9 | 32 |
| 5 |
|
Almere City FC | 17 | 9 | 2 | 6 | 27:22 | 5 | 29 |
| 6 |
|
VVV-Venlo | 17 | 8 | 4 | 5 | 26:26 | 0 | 28 |
| 7 |
|
Jong AZ Alkmaar | 17 | 8 | 3 | 6 | 30:23 | 7 | 27 |
| 8 |
|
Willem II | 17 | 6 | 6 | 5 | 24:21 | 3 | 24 |
| 9 |
|
Roda JC Kerkrade | 17 | 7 | 3 | 7 | 27:25 | 2 | 24 |
| 10 |
|
Jong PSV | 17 | 6 | 5 | 6 | 28:27 | 1 | 23 |
| 11 |
|
Telstar | 17 | 5 | 7 | 5 | 16:23 | -7 | 22 |
| 12 |
|
Jong Ajax | 17 | 5 | 6 | 6 | 31:30 | 1 | 21 |
| 13 |
|
De Graafschap | 17 | 6 | 3 | 8 | 26:27 | -1 | 21 |
| 14 |
|
NAC Breda | 17 | 6 | 3 | 8 | 23:30 | -7 | 21 |
| 15 |
|
FC Dordrecht | 17 | 5 | 4 | 8 | 22:27 | -5 | 19 |
| 16 |
|
FC Den Bosch | 17 | 6 | 1 | 10 | 26:32 | -6 | 19 |
| 17 |
|
ADO Den Haag | 17 | 4 | 4 | 9 | 20:30 | -10 | 16 |
| 18 |
|
Helmond Sport | 17 | 5 | 0 | 12 | 13:31 | -18 | 15 |
| 19 |
|
TOP Oss | 17 | 4 | 1 | 12 | 17:32 | -15 | 13 |
| 20 |
|
Jong FC Utrecht | 17 | 3 | 3 | 11 | 15:29 | -14 | 12 |
| Promotie | |
| Play-offs |
