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| 15.12.2005 | 20:00 | Helmond Sport | - | FC Den Bosch | 4:2 (2:1) | |
| 16.12.2005 | 20:00 | FC Omniworld | - | FC Eindhoven | 3:2 (1:0) | |
| 20:00 | MVV Maastricht | - | De Graafschap | 1:0 (0:0) | ||
| 20:00 | VVV-Venlo | - | AGOVV | 3:0 (2:0) | ||
| 20:00 | HFC Haarlem | - | FC Volendam | 4:0 (3:0) | ||
| 20:00 | TOP Oss | - | BV Veendam | 0:2 (0:0) | ||
| 20:00 | Fortuna Sittard | - | Stormvogels Telstar | 0:0 (0:0) | ||
| 20:00 | FC Zwolle | - | FC Dordrecht | 0:1 (0:0) | ||
| 20:00 | SC Cambuur | - | Go Ahead Eagles | 2:1 (0:0) | ||
| 20:00 | FC Emmen | - | SBV Excelsior | 0:2 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 23 | 15 | 4 | 4 | 45:13 | 32 | 49 |
| 2 |
|
VVV-Venlo | 23 | 14 | 6 | 3 | 36:12 | 24 | 48 |
| 3 |
|
FC Emmen | 23 | 13 | 3 | 7 | 46:28 | 18 | 42 |
| 4 |
|
Helmond Sport | 23 | 12 | 4 | 7 | 37:35 | 2 | 40 |
| 5 |
|
FC Zwolle | 23 | 11 | 6 | 6 | 41:28 | 13 | 39 |
| 6 |
|
FC Volendam | 23 | 11 | 6 | 6 | 35:26 | 9 | 39 |
| 7 |
|
FC Den Bosch | 23 | 10 | 8 | 5 | 43:34 | 9 | 38 |
| 8 |
|
MVV Maastricht | 23 | 9 | 7 | 7 | 32:28 | 4 | 34 |
| 9 |
|
De Graafschap | 23 | 9 | 6 | 8 | 32:28 | 4 | 33 |
| 10 |
|
FC Dordrecht | 23 | 8 | 8 | 7 | 28:25 | 3 | 32 |
| 11 |
|
BV Veendam | 23 | 9 | 5 | 9 | 31:30 | 1 | 32 |
| 12 |
|
AGOVV | 23 | 9 | 3 | 11 | 41:41 | 0 | 30 |
| 13 |
|
HFC Haarlem | 23 | 8 | 5 | 10 | 30:41 | -11 | 29 |
| 14 |
|
TOP Oss | 23 | 7 | 7 | 9 | 28:37 | -9 | 28 |
| 15 |
|
Go Ahead Eagles | 23 | 6 | 7 | 10 | 28:38 | -10 | 25 |
| 16 |
|
Stormvogels Telstar | 23 | 5 | 8 | 10 | 18:31 | -13 | 23 |
| 17 |
|
FC Eindhoven | 23 | 5 | 5 | 13 | 31:38 | -7 | 20 |
| 18 |
|
SC Cambuur | 23 | 4 | 9 | 10 | 21:34 | -13 | 18 |
| 19 |
|
FC Omniworld | 23 | 4 | 5 | 14 | 27:54 | -27 | 17 |
| 20 |
|
Fortuna Sittard | 23 | 1 | 8 | 14 | 21:50 | -29 | 11 |
| Promotie |
