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| 05.11.2010 | 18:45 | RBC Roosendaal | - | FC Den Bosch | 2:2 (1:1) | |
| 20:00 | FC Dordrecht | - | MVV Maastricht | 1:0 (0:0) | ||
| 20:00 | BV Veendam | - | RKC Waalwijk | 3:3 (1:2) | ||
| 20:00 | Almere City FC | - | Telstar | 0:0 (0:0) | ||
| 20:00 | AGOVV | - | FC Emmen | 2:2 (0:0) | ||
| 20:00 | Go Ahead Eagles | - | Fortuna Sittard | 3:0 (1:0) | ||
| 20:00 | FC Volendam | - | SC Cambuur | 2:1 (1:0) | ||
| 20:00 | FC Eindhoven | - | FC Zwolle | 1:2 (0:2) | ||
| 20:00 | Sparta Rotterdam | - | Helmond Sport | 1:1 (1:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Zwolle | 12 | 9 | 2 | 1 | 28:9 | 19 | 28 |
| 2 |
|
FC Volendam | 12 | 8 | 4 | 0 | 24:12 | 12 | 28 |
| 3 |
|
RKC Waalwijk | 12 | 5 | 6 | 1 | 27:15 | 12 | 21 |
| 4 |
|
Helmond Sport | 12 | 6 | 3 | 3 | 18:14 | 4 | 21 |
| 5 |
|
FC Den Bosch | 12 | 5 | 5 | 2 | 28:21 | 7 | 20 |
| 6 |
|
Sparta Rotterdam | 12 | 5 | 4 | 3 | 34:20 | 14 | 19 |
| 7 |
|
Go Ahead Eagles | 12 | 6 | 1 | 5 | 27:13 | 14 | 19 |
| 8 |
|
FC Eindhoven | 12 | 5 | 4 | 3 | 19:13 | 6 | 19 |
| 9 |
|
SC Cambuur | 12 | 5 | 2 | 5 | 17:15 | 2 | 14 |
| 10 |
|
FC Dordrecht | 12 | 5 | 1 | 6 | 16:22 | -6 | 12 |
| 11 |
|
RBC Roosendaal | 12 | 4 | 2 | 6 | 17:17 | 0 | 11 |
| 12 |
|
BV Veendam | 12 | 3 | 6 | 3 | 17:21 | -4 | 11 |
| 13 |
|
FC Emmen | 12 | 2 | 4 | 6 | 17:28 | -11 | 10 |
| 14 |
|
Telstar | 12 | 1 | 5 | 6 | 13:21 | -8 | 8 |
| 15 |
|
AGOVV | 12 | 5 | 1 | 6 | 20:25 | -5 | 7 |
| 16 |
|
Fortuna Sittard | 12 | 1 | 2 | 9 | 14:32 | -18 | 3 |
| 17 |
|
MVV Maastricht | 12 | 2 | 4 | 6 | 12:21 | -9 | 2 |
| 18 |
|
Almere City FC | 12 | 2 | 2 | 8 | 11:40 | -29 | 2 |
| Promotie | |
| Play-offs | |
| Play-offs | |
| Degradatie |
