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| 19.04.2022 | 19:00 | RCD Mallorca | - | Deportivo Alavés | 2:1 (2:0) | |
| 21:00 | Real Betis | - | Elche CF | 0:1 (0:0) | ||
| 21:30 | Villarreal CF | - | Valencia CF | 2:0 (2:0) | ||
| 20.04.2022 | 19:00 | Atlético Madrid | - | Granada CF | 0:0 (0:0) | |
| 20:00 | Celta de Vigo | - | Getafe CF | 0:2 (0:1) | ||
| 21:30 | CA Osasuna | - | Real Madrid | 1:3 (1:2) | ||
| 21.04.2022 | 19:00 | Espanyol | - | Rayo Vallecano | 0:1 (0:1) | |
| 19:00 | Levante UD | - | Sevilla FC | 2:3 (1:2) | ||
| 20:00 | Cádiz CF | - | Athletic Bilbao | 2:3 (0:3) | ||
| 21:30 | Real Sociedad | - | FC Barcelona | 0:1 (0:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Real Madrid | 33 | 24 | 6 | 3 | 69:29 | 40 | 78 |
| 2 |
|
FC Barcelona | 33 | 18 | 9 | 6 | 61:33 | 28 | 63 |
| 3 |
|
Sevilla FC | 33 | 17 | 12 | 4 | 49:27 | 22 | 63 |
| 4 |
|
Atlético Madrid | 33 | 18 | 7 | 8 | 59:39 | 20 | 61 |
| 5 |
|
Real Betis | 33 | 17 | 6 | 10 | 56:38 | 18 | 57 |
| 6 |
|
Real Sociedad | 33 | 15 | 10 | 8 | 32:31 | 1 | 55 |
| 7 |
|
Villarreal CF | 33 | 14 | 10 | 9 | 53:31 | 22 | 52 |
| 8 |
|
Athletic Bilbao | 33 | 12 | 12 | 9 | 39:34 | 5 | 48 |
| 9 |
|
CA Osasuna | 33 | 12 | 8 | 13 | 34:44 | -10 | 44 |
| 10 |
|
Valencia CF | 33 | 10 | 12 | 11 | 44:48 | -4 | 42 |
| 11 |
|
Rayo Vallecano | 33 | 11 | 7 | 15 | 34:38 | -4 | 40 |
| 12 |
|
Celta de Vigo | 33 | 10 | 9 | 14 | 36:37 | -1 | 39 |
| 13 |
|
Espanyol | 33 | 10 | 9 | 14 | 37:45 | -8 | 39 |
| 14 |
|
Elche CF | 33 | 10 | 8 | 15 | 36:44 | -8 | 38 |
| 15 |
|
Getafe CF | 33 | 8 | 11 | 14 | 31:37 | -6 | 35 |
| 16 |
|
RCD Mallorca | 33 | 8 | 8 | 17 | 29:54 | -25 | 32 |
| 17 |
|
Cádiz CF | 33 | 6 | 13 | 14 | 29:46 | -17 | 31 |
| 18 |
|
Granada CF | 33 | 6 | 12 | 15 | 36:56 | -20 | 30 |
| 19 |
|
Levante UD | 33 | 5 | 10 | 18 | 41:65 | -24 | 25 |
| 20 |
|
Deportivo Alavés | 33 | 6 | 7 | 20 | 26:55 | -29 | 25 |
| Champions League | |
| Europa League | |
| Degradatie |
