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| 14.05.2022 | 15:00 | Altınordu FK | - | Balıkesirspor | 2:1 (0:1) | |
| 15:00 | MKE Ankaragücü | - | Boluspor | 1:2 (0:1) | ||
| 15:00 | Bandırmaspor | - | Bursaspor | 4:2 (2:2) | ||
| 15:00 | BB Erzurumspor | - | Keçiörengücü | 2:2 (2:0) | ||
| 15:00 | Eyüpspor | - | Kocaelispor | 2:1 (2:0) | ||
| 15:00 | Manisa FK | - | Tuzlaspor | 4:1 (2:1) | ||
| 15:00 | Menemen Belediyespor | - | Gençlerbirliği | 1:3 (0:0) | ||
| 15:00 | Samsunspor | - | İstanbulspor AŞ | 0:0 (0:0) | ||
| 15:00 | Ümraniyespor | - | Denizlispor | 0:0 (0:0) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 35 | 20 | 7 | 8 | 54:30 | 24 | 67 |
| 2 |
|
Ümraniyespor | 35 | 20 | 7 | 8 | 60:35 | 25 | 67 |
| 3 |
|
Bandırmaspor | 35 | 19 | 4 | 12 | 56:34 | 22 | 61 |
| 4 |
|
İstanbulspor AŞ | 35 | 17 | 8 | 10 | 57:40 | 17 | 59 |
| 5 |
|
BB Erzurumspor | 35 | 16 | 10 | 9 | 55:40 | 15 | 58 |
| 6 |
|
Eyüpspor | 35 | 14 | 12 | 9 | 53:44 | 9 | 54 |
| 7 |
|
Tuzlaspor | 35 | 13 | 10 | 12 | 43:40 | 3 | 49 |
| 8 |
|
Manisa FK | 36 | 14 | 7 | 15 | 45:44 | 1 | 49 |
| 9 |
|
Samsunspor | 35 | 12 | 12 | 11 | 50:44 | 6 | 48 |
| 10 |
|
Keçiörengücü | 35 | 13 | 9 | 13 | 44:45 | -1 | 48 |
| 11 |
|
Gençlerbirliği | 35 | 14 | 6 | 15 | 42:50 | -8 | 48 |
| 12 |
|
Boluspor | 35 | 13 | 8 | 14 | 40:43 | -3 | 47 |
| 13 |
|
Denizlispor | 35 | 13 | 7 | 15 | 42:50 | -8 | 46 |
| 14 |
|
Altınordu FK | 35 | 14 | 3 | 18 | 44:60 | -16 | 45 |
| 15 |
|
Adanaspor | 35 | 12 | 9 | 14 | 39:40 | -1 | 45 |
| 16 |
|
Bursaspor | 35 | 11 | 8 | 16 | 42:53 | -11 | 41 |
| 17 |
|
Kocaelispor | 35 | 11 | 8 | 16 | 36:48 | -12 | 41 |
| 18 |
|
Menemen Belediyespor | 35 | 8 | 14 | 13 | 42:56 | -14 | 38 |
| 19 |
|
Balıkesirspor | 35 | 3 | 3 | 29 | 26:74 | -48 | 12 |
| Promotie | |
| Play-offs | |
| Degradatie |
