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| 26.03.2022 | 11:00 | Hannover 96 | - | Chemnitzer FC | 2:1 (1:0) | |
| 02.04.2022 | 11:00 | Energie Cottbus | - | Eintracht Braunschweig | 3:0 (1:0) | |
| 11:00 | Erzgebirge Aue | - | Hamburger SV | 1:1 (0:0) | ||
| 11:00 | Dynamo Dresden | - | Hansa Rostock | 4:0 (2:0) | ||
| 13:00 | Hertha BSC | - | VfL Wolfsburg | 4:3 (2:1) | ||
| 13:00 | FC St. Pauli | - | Werder Bremen | 2:1 (1:0) | ||
| 14:00 | FC Viktoria 1889 Berlin | - | Hertha Zehlendorf | 2:1 (1:0) | ||
| 03.04.2022 | 11:00 | RB Leipzig | - | Holstein Kiel | 3:2 (1:2) | |
| 13:30 | 1. FC Union Berlin | - | FC Carl Zeiss Jena | 0:1 (0:0) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Hertha BSC | 16 | 14 | 2 | 0 | 51:8 | 43 | 44 |
| 2 |
|
Hamburger SV | 16 | 11 | 3 | 2 | 37:14 | 23 | 36 |
| 3 |
|
FC St. Pauli | 16 | 11 | 2 | 3 | 36:11 | 25 | 35 |
| 4 |
|
VfL Wolfsburg | 17 | 9 | 5 | 3 | 41:20 | 21 | 32 |
| 5 |
|
Dynamo Dresden | 16 | 10 | 1 | 5 | 31:19 | 12 | 31 |
| 6 |
|
Chemnitzer FC | 16 | 10 | 1 | 5 | 25:18 | 7 | 31 |
| 7 |
|
Werder Bremen | 16 | 9 | 1 | 6 | 37:27 | 10 | 28 |
| 8 |
|
RB Leipzig | 16 | 8 | 3 | 5 | 30:21 | 9 | 27 |
| 9 |
|
1. FC Union Berlin | 17 | 8 | 2 | 7 | 22:21 | 1 | 26 |
| 10 |
|
Hannover 96 | 16 | 8 | 2 | 6 | 23:26 | -3 | 26 |
| 11 |
|
FC Viktoria 1889 Berlin | 16 | 7 | 0 | 9 | 22:29 | -7 | 21 |
| 12 |
|
Hansa Rostock | 16 | 6 | 2 | 8 | 22:27 | -5 | 20 |
| 13 |
|
Holstein Kiel | 16 | 4 | 3 | 9 | 24:37 | -13 | 15 |
| 14 |
|
Erzgebirge Aue | 16 | 3 | 5 | 8 | 12:28 | -16 | 14 |
| 15 |
|
Energie Cottbus | 16 | 4 | 2 | 10 | 17:40 | -23 | 14 |
| 16 |
|
FC Carl Zeiss Jena | 16 | 4 | 1 | 11 | 10:24 | -14 | 13 |
| 17 |
|
Eintracht Braunschweig | 16 | 2 | 4 | 10 | 11:28 | -17 | 10 |
| 18 |
|
Hertha Zehlendorf | 16 | 3 | 0 | 13 | 15:30 | -15 | 9 |
| 19 |
|
Hallescher FC | 16 | 1 | 3 | 12 | 9:47 | -38 | 6 |
| Play-offs | |
| Degradatie |
