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| 05.06.2022 | 15:00 | Fortuna Köln II | - | Blau-Weiß Friesdorf | 8:0 (3:0) | |
| 06.06.2022 | 15:00 | SV Bergisch Gladbach 09 | - | 1. FC Düren | 3:3 (2:1) | |
| 15:00 | SV 1914 Eilendorf | - | SV Deutz 05 | 4:1 (3:1) | ||
| 15:00 | Spvg Wesseling-Urfeld | - | BC Viktoria Glesch-Paffendorf | 0:4 (0:2) | ||
| 15:00 | Borussia Freialdenhoven | - | FC Hennef 05 | 3:0 (2:0) | ||
| 15:00 | Viktoria Arnoldsweiler | - | VfL Alfter | 1:1 (0:0) | ||
| 15:00 | SV Breinig | - | VfL 08 Vichttal | 3:2 (2:0) | ||
| 15:30 | Siegburger SV 04 | - | FC Pesch 1956 | 3:1 (0:1) | ||
| 15:30 | SpVg Frechen 20 | - | FC Hürth | 0:3 (0:1) |
| » Stand | Thuis | uit | Heenronde | Returnronde |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Düren | 33 | 26 | 6 | 1 | 108:22 | 86 | 84 |
| 2 |
|
SV Bergisch Gladbach 09 | 33 | 22 | 9 | 2 | 89:24 | 65 | 75 |
| 3 |
|
FC Hennef 05 | 33 | 23 | 4 | 6 | 82:32 | 50 | 73 |
| 4 |
|
SpVg Frechen 20 | 33 | 19 | 5 | 9 | 66:45 | 21 | 62 |
| 5 |
|
Borussia Freialdenhoven | 33 | 17 | 5 | 11 | 61:58 | 3 | 56 |
| 6 |
|
Blau-Weiß Friesdorf | 33 | 14 | 8 | 11 | 67:62 | 5 | 50 |
| 7 |
|
FC Hürth | 33 | 15 | 5 | 13 | 52:62 | -10 | 50 |
| 8 |
|
Siegburger SV 04 | 33 | 13 | 10 | 10 | 56:46 | 10 | 49 |
| 9 |
|
Viktoria Arnoldsweiler | 33 | 14 | 4 | 15 | 59:55 | 4 | 46 |
| 10 |
|
FC Pesch 1956 | 33 | 11 | 11 | 11 | 67:57 | 10 | 44 |
| 11 |
|
BC Viktoria Glesch-Paffendorf | 33 | 12 | 7 | 14 | 48:47 | 1 | 43 |
| 12 |
|
VfL 08 Vichttal | 33 | 12 | 5 | 16 | 59:74 | -15 | 41 |
| 13 |
|
VfL Alfter | 33 | 11 | 5 | 17 | 48:57 | -9 | 38 |
| 14 |
|
SV 1914 Eilendorf | 33 | 11 | 5 | 17 | 37:56 | -19 | 38 |
| 15 |
|
Fortuna Köln II | 33 | 10 | 6 | 17 | 65:68 | -3 | 36 |
| 16 |
|
SV Breinig | 33 | 7 | 3 | 23 | 44:92 | -48 | 24 |
| 17 |
|
SV Deutz 05 | 33 | 5 | 3 | 25 | 37:91 | -54 | 18 |
| 18 |
|
Spvg Wesseling-Urfeld | 33 | 4 | 1 | 28 | 33:130 | -97 | 13 |
| Play-offs | |
| Degradatie |
