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| U | Santiago Wanderers | - | Santa Fe | 1:2 (0:2) | ||
| R | Santa Fe | - | Santiago Wanderers | 3:0 (1:0) | ||
| U: 14.02.2018 01:30 | R: 21.02.2018 01:30 | Winnaars: Santa Fe | ||||
| U | Banfield | - | Nacional | 2:2 (0:0) | ||
| R | Nacional | - | Banfield | 1:0 (0:0) | ||
| U: 14.02.2018 23:00 | R: 22.02.2018 01:45 | Winnaars: Nacional | ||||
| U | Vasco da Gama - RJ | - | Jorge Wilstermann | 4:0 (2:0) | ||
| R | Jorge Wilstermann | - | Vasco da Gama - RJ | 2:3 (3:0, 4:0) d.p. | ||
| U: 15.02.2018 00:45 | R: 22.02.2018 01:45 | Winnaars: Vasco da Gama - RJ | ||||
| U | Atlético Junior | - | Guaraní | 1:0 (0:0) | ||
| R | Guaraní | - | Atlético Junior | 0:0 (0:0) | ||
| U: 15.02.2018 23:15 | R: 23.02.2018 01:30 | Winnaars: Atlético Junior | ||||
