| 1. Ronde | 28.08.2021 | SBV Excelsior [U21] | - | Willem II [U21] | 0:1 |  |
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| 2. Ronde | 11.09.2021 | Willem II [U21] | - | PEC Zwolle [U21] | 1:1 | ||||
| 6. Ronde | 16.10.2021 | Willem II [U21] | - | De Graafschap [U21] | 1:2 | ||||
| 8. Ronde | 31.10.2021 | Willem II [U21] | - | Roda JC Kerkrade [U21] | 1:0 | ||||
| 9. Ronde | 06.11.2021 | Alphense Boys [U21] | - | Willem II [U21] | 0:3 |  |
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| 10. Ronde | 20.11.2021 | Willem II [U21] | - | Vitesse [U21] | 4:1 | |
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| 11. Ronde | 27.11.2021 | PEC Zwolle [U21] | - | Willem II [U21] | 2:2 | ||||
| 12. Ronde | 05.02.2022 | Willem II [U21] | - | SBV Excelsior [U21] | 1:2 | ||||
| 13. Ronde | 12.02.2022 | Willem II [U21] | - | FC Emmen [U21] | 1:2 |
Nederland