| 1. Ronde | 29.07.2021 | AD San Carlos | - | LD Alajuelense | 2:2 |  |
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| 2. Ronde | 01.08.2021 | Guadalupe | - | AD San Carlos | 1:1 | |
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| 3. Ronde | 07.08.2021 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 4. Ronde | 11.08.2021 | CS Cartaginés | - | AD San Carlos | 5:1 | |
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| 5. Ronde | 14.08.2021 | AD San Carlos | - | Jicaral | 0:0 | ||||
| 6. Ronde | 18.08.2021 | CS Herediano | - | AD San Carlos | 2:0 | ||||
| 7. Ronde | 25.08.2021 | Sporting FC | - | AD San Carlos | 0:0 | ||||
| 8. Ronde | 30.08.2021 | AD San Carlos | - | AD Guanacasteca | 0:1 | ||||
| 9. Ronde | 08.09.2021 | Santos de Guápiles | - | AD San Carlos | 2:2 | ||||
| 10. Ronde | 13.09.2021 | AD San Carlos | - | Deportivo Saprissa | 1:0 | |
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| 11. Ronde | 15.09.2021 | Municipal Grecia | - | AD San Carlos | 3:2 | ||||
| 19. Ronde | 01.11.2021 | AD Guanacasteca | - | AD San Carlos | 0:1 | |
Panama