| 3. Ronde | 06.02.2010 | Nacional | - | Defensor Sporting | 0:1 | ||||
| 4. Ronde | 13.02.2010 | Defensor Sporting | - | Central Español | 3:4 |  |
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| 5. Ronde | 21.02.2010 | Fénix | - | Defensor Sporting | 3:0 | ||||
| 6. Ronde | 27.02.2010 | Defensor Sporting | - | Rampla Juniors | 2:1 | ||||
| 7. Ronde | 07.03.2010 | Cerrito | - | Defensor Sporting | 2:0 | ||||
| 8. Ronde | 13.03.2010 | Cerro Largo | - | Defensor Sporting | 1:3 | ||||
| 9. Ronde | 20.03.2010 | Defensor Sporting | - | Tacuarembó | 2:3 | ||||
| 10. Ronde | 28.03.2010 | Defensor Sporting | - | Peñarol | 2:3 | |
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| 11. Ronde | 03.04.2010 | Racing | - | Defensor Sporting | 3:3 | ||||
| 12. Ronde | 09.04.2010 | Defensor Sporting | - | CA Cerro | 1:0 | ||||
| 13. Ronde | 17.04.2010 | Defensor Sporting | - | River Plate | 1:1 | ||||
| 14. Ronde | 25.04.2010 | Defensor Sporting | - | Montevideo Wanderers | 2:0 | ||||
| 15. Ronde | 02.05.2010 | Liverpool | - | Defensor Sporting | 3:0 | |
Uruguay