| 1. Ronde | 12.03.2022 | Almere City FC [U21] | - | FC Groningen [U21] | 4:3 |  |
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| 2. Ronde | 19.03.2022 | FC Groningen [U21] | - | ADO Den Haag [U21] | 1:0 | ||||
| 3. Ronde | 02.04.2022 | NAC Breda [U21] | - | FC Groningen [U21] | 1:1 | |
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| 4. Ronde | 09.04.2022 | Feyenoord [U21] | - | FC Groningen [U21] | 1:0 | ||||
| 5. Ronde | 23.04.2022 | FC Groningen [U21] | - | Willem II [U21] | 1:2 | |
Zweden