| 4. Ronde | 12.08.2021 | Santos de Guápiles | - | LD Alajuelense | 2:1 | ||||
| 5. Ronde | 15.08.2021 | Santos de Guápiles | - | AD Guanacasteca | 2:1 |  |
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| 6. Ronde | 21.08.2021 | Jicaral | - | Santos de Guápiles | 1:1 | |
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| 13. Ronde | 26.09.2021 | Municipal Grecia | - | Santos de Guápiles | 3:2 | ||||
| 14. Ronde | 03.10.2021 | Santos de Guápiles | - | Sporting FC | 5:1 | ||||
| 16. Ronde | 17.10.2021 | AD Guanacasteca | - | Santos de Guápiles | 1:3 | ||||
| 17. Ronde | 24.10.2021 | Santos de Guápiles | - | Jicaral | 2:3 | ||||
| 18. Ronde | 28.10.2021 | CS Herediano | - | Santos de Guápiles | 1:1 | ||||
| 20. Ronde | 21.11.2021 | AD San Carlos | - | Santos de Guápiles | 2:4 |
Costa Rica