| 7. Ronde | 23.06.2021 | Cerrito | - | Boston River | 1:0 | ||||
| 8. Ronde | 27.06.2021 | Boston River | - | Liverpool | 1:1 | ||||
| 9. Ronde | 03.07.2021 | River Plate | - | Boston River | 1:1 | ||||
| 10. Ronde | 11.07.2021 | Boston River | - | Cerro Largo | 1:0 | ||||
| 12. Ronde | 31.07.2021 | Boston River | - | Sud América | 2:0 | ||||
| 13. Ronde | 09.08.2021 | Plaza Colonia | - | Boston River | 0:0 | ||||
| 14. Ronde | 16.08.2021 | Boston River | - | Fénix | 0:2 | ||||
| 15. Ronde | 21.08.2021 | Deportivo Maldonado | - | Boston River | 0:2 |
Uruguay