| 3. Ronde | 01.08.2021 | Cusco FC | - | Alianza Universidad | 2:3 | ||||
| 4. Ronde | 04.08.2021 | FBC Melgar | - | Cusco FC | 2:2 | ||||
| 5. Ronde | 08.08.2021 | Cusco FC | - | Alianza Atlético | 3:0 | ||||
| 6. Ronde | 13.08.2021 | Universidad Técnica | - | Cusco FC | 2:1 | ||||
| 7. Ronde | 17.08.2021 | Cusco FC | - | Mannucci | 2:3 | ||||
| 8. Ronde | 23.08.2021 | Sporting Cristal | - | Cusco FC | 4:1 | ||||
| 10. Ronde | 11.09.2021 | Ayacucho FC | - | Cusco FC | 1:3 |  |
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| 16. Ronde | 23.10.2021 | Universitario de Deportes | - | Cusco FC | 2:1 | ||||
| 17. Ronde | 30.10.2021 | Cusco FC | - | Sport Huancayo | 2:1 |
Peru