| 1. Ronde | 09.07.2016 | Libertad | - | River Plate | 1:1 | ||||
| 3. Ronde | 20.07.2016 | Guaraní | - | River Plate | 2:0 |  |
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| 4. Ronde | 25.07.2016 | River Plate | - | Club Olimpia | 0:2 | ||||
| 7. Ronde | 12.08.2016 | Sportivo Luqueño | - | River Plate | 1:0 | ||||
| 8. Ronde | 20.08.2016 | Deportivo Capiatá | - | River Plate | 0:3 |  |
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| 9. Ronde | 29.08.2016 | River Plate | - | Cerro Porteño | 2:3 | |
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| 10. Ronde | 10.09.2016 | Sol de América | - | River Plate | 2:6 | |
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| 11. Ronde | 18.09.2016 | River Plate | - | Club Nacional | 2:3 | ||||
| 12. Ronde | 24.09.2016 | River Plate | - | Libertad | 2:0 | ||||
| 13. Ronde | 30.09.2016 | General Díaz | - | River Plate | 2:0 | ||||
| 14. Ronde | 17.10.2016 | River Plate | - | Guaraní | 0:2 | |
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| 15. Ronde | 23.10.2016 | Club Olimpia | - | River Plate | 5:3 | ||||
| 16. Ronde | 29.10.2016 | River Plate | - | Club Rubio Ñu | 0:2 | ||||
| 17. Ronde | 05.11.2016 | General Caballero ZC | - | River Plate | 1:0 | ||||
| 19. Ronde | 26.11.2016 | River Plate | - | Deportivo Capiatá | 2:4 | ||||
| 20. Ronde | 02.12.2016 | Cerro Porteño | - | River Plate | 4:0 | ||||
| 21. Ronde | 11.12.2016 | River Plate | - | Sol de América | 2:4 | |
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| 22. Ronde | 18.12.2016 | Club Nacional | - | River Plate | 2:0 |
Paraguay