| 1. Ronde | 01.08.2021 | Luis Ángel Firpo | - | Jocoro FC | 1:1 | ||||
| 2. Ronde | 08.08.2021 | Municipal Limeño | - | Luis Ángel Firpo | 1:1 | ||||
| 4. Ronde | 15.08.2021 | Alianza | - | Luis Ángel Firpo | 2:2 | ||||
| 5. Ronde | 22.08.2021 | AD Chalatenango | - | Luis Ángel Firpo | 0:2 | ||||
| 6. Ronde | 25.08.2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 | ||||
| 7. Ronde | 29.08.2021 | FAS | - | Luis Ángel Firpo | 3:1 | ||||
| 8. Ronde | 12.09.2021 | Luis Ángel Firpo | - | Isidro Metapán | 1:1 | ||||
| 9. Ronde | 15.09.2021 | Atlético Marte | - | Luis Ángel Firpo | 1:3 |  |
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| 10. Ronde | 19.09.2021 | Luis Ángel Firpo | - | Santa Tecla FC | 0:0 | |
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| 11. Ronde | 26.09.2021 | CD Águila | - | Luis Ángel Firpo | 1:1 | ||||
| 12. Ronde | 02.10.2021 | Jocoro FC | - | Luis Ángel Firpo | 2:1 | ||||
| 13. Ronde | 17.10.2021 | Luis Ángel Firpo | - | Municipal Limeño | 1:1 | |
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| 15. Ronde | 24.10.2021 | Luis Ángel Firpo | - | Alianza | 2:1 | |
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| 16. Ronde | 31.10.2021 | Luis Ángel Firpo | - | AD Chalatenango | 4:2 | ||||
| 17. Ronde | 02.11.2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 22. Ronde | 27.11.2021 | Luis Ángel Firpo | - | CD Águila | 1:0 |
El Salvador