| 4. Ronde | 26.02.2022 | Montevideo Wanderers | - | Defensor Sporting | 1:0 | ||||
| 5. Ronde | 12.03.2022 | Defensor Sporting | - | Plaza Colonia | 0:0 | ||||
| 6. Ronde | 21.03.2022 | Boston River | - | Defensor Sporting | 1:1 |  |
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| 7. Ronde | 03.04.2022 | Defensor Sporting | - | River Plate | 3:2 | |
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| 8. Ronde | 09.04.2022 | Cerro Largo | - | Defensor Sporting | 0:0 | ||||
| 9. Ronde | 16.04.2022 | Defensor Sporting | - | Fénix | 2:1 | ||||
| 10. Ronde | 26.04.2022 | Defensor Sporting | - | Cerrito | 0:0 | ||||
| 11. Ronde | 07.05.2022 | Albion | - | Defensor Sporting | 0:3 | |
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| 12. Ronde | 14.05.2022 | Defensor Sporting | - | Nacional | 0:2 | ||||
| 13. Ronde | 22.05.2022 | Danubio | - | Defensor Sporting | 1:2 | |
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| 15. Ronde | 05.06.2022 | Rentistas | - | Defensor Sporting | 1:0 |
Uruguay