| 2. Ronde | 19.09.2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 | ||||
| 3. Ronde | 22.09.2021 | Panetolikos | - | PAOK Saloniki | 1:2 | ||||
| 4. Ronde | 26.09.2021 | PAOK Saloniki | - | AEK Athene | 2:0 |  |
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| 5. Ronde | 03.10.2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
| 6. Ronde | 17.10.2021 | PAOK Saloniki | - | Volos NFC | 4:4 | |
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| 7. Ronde | 24.10.2021 | Olympiakos | - | PAOK Saloniki | 2:1 | ||||
| 9. Ronde | 07.11.2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | ||||
| 10. Ronde | 21.11.2021 | Atromitos | - | PAOK Saloniki | 2:0 | ||||
| 12. Ronde | 05.12.2021 | Ionikos Nikea | - | PAOK Saloniki | 3:2 | |
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| 13. Ronde | 12.12.2021 | PAOK Saloniki | - | Lamia | 2:1 | ||||
| 19. Ronde | 23.01.2022 | Volos NFC | - | PAOK Saloniki | 0:4 |
Nigeria