| 1. Ronde | 01.08.2021 | FAS | - | Santa Tecla FC | 3:1 |  |
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| 2. Ronde | 08.08.2021 | CD Águila | - | FAS | 1:1 | |
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| 4. Ronde | 15.08.2021 | Municipal Limeño | - | FAS | 0:3 | |
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| 6. Ronde | 26.08.2021 | Alianza | - | FAS | 1:0 | |
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| 7. Ronde | 29.08.2021 | FAS | - | Luis Ángel Firpo | 3:1 | ||||
| 8. Ronde | 12.09.2021 | Once Municipal | - | FAS | 1:3 | ||||
| 9. Ronde | 16.09.2021 | AD Chalatenango | - | FAS | 1:2 | ||||
| 10. Ronde | 19.09.2021 | FAS | - | Isidro Metapán | 3:0 | |
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| 12. Ronde | 03.10.2021 | Santa Tecla FC | - | FAS | 1:0 | ||||
| 13. Ronde | 18.10.2021 | FAS | - | CD Águila | 0:1 | ||||
| 16. Ronde | 30.10.2021 | Platense Zacatecoluca | - | FAS | 0:0 |  |
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| 18. Ronde | 07.11.2021 | Luis Ángel Firpo | - | FAS | 2:0 | ||||
| 19. Ronde | 14.11.2021 | FAS | - | Once Municipal | 3:2 | ||||
| 20. Ronde | 17.11.2021 | FAS | - | AD Chalatenango | 1:1 | ||||
| 21. Ronde | 22.11.2021 | Isidro Metapán | - | FAS | 1:2 | ||||
| 22. Ronde | 27.11.2021 | FAS | - | Atlético Marte | 2:2 |
El Salvador