| 1. Ronde | 16.01.2022 | Once Municipal | - | FAS | 1:1 | ||||
| 3. Ronde | 26.01.2022 | Jocoro FC | - | FAS | 2:2 |  |
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| 7. Ronde | 13.02.2022 | FAS | - | Atlético Marte | 3:0 | ||||
| 8. Ronde | 20.02.2022 | Isidro Metapán | - | FAS | 1:1 | |
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| 9. Ronde | 23.02.2022 | FAS | - | AD Chalatenango | 1:3 | ||||
| 10. Ronde | 27.02.2022 | Luis Ángel Firpo | - | FAS | 2:3 | ||||
| 4. Ronde | 03.03.2022 | Alianza | - | FAS | 1:1 | |
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| 11. Ronde | 06.03.2022 | FAS | - | Platense Zacatecoluca | 2:1 | ||||
| 12. Ronde | 13.03.2022 | FAS | - | Once Municipal | 0:0 | ||||
| 14. Ronde | 23.03.2022 | FAS | - | Jocoro FC | 2:1 | ||||
| 15. Ronde | 03.04.2022 | FAS | - | Alianza | 1:3 | |
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| 17. Ronde | 13.04.2022 | FAS | - | Municipal Limeño | 1:1 | ||||
| 18. Ronde | 17.04.2022 | Atlético Marte | - | FAS | 1:1 | ||||
| 19. Ronde | 24.04.2022 | FAS | - | Isidro Metapán | 4:1 | |
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| 21. Ronde | 01.05.2022 | FAS | - | Luis Ángel Firpo | 0:1 | |
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| 22. Ronde | 07.05.2022 | Platense Zacatecoluca | - | FAS | 1:2 |
El Salvador