| 11. Ronde | 10.09.2022 | Patriotas FC | - | Deportes Tolima | 1:1 |  |
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| 12. Ronde | 17.09.2022 | Deportes Tolima | - | Once Caldas | 1:0 |  |
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| 13. Ronde | 22.09.2022 | América de Cali | - | Deportes Tolima | 0:0 | ||||
| 14. Ronde | 26.09.2022 | Deportes Tolima | - | Deportivo Pereira | 1:3 | |
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| 15. Ronde | 02.10.2022 | Águilas Doradas | - | Deportes Tolima | 1:2 | ||||
| 16. Ronde | 09.10.2022 | Deportivo Pasto | - | Deportes Tolima | 2:1 | |
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| 17. Ronde | 13.10.2022 | Deportes Tolima | - | Alianza Petrolera | 2:0 | ||||
| 18. Ronde | 16.10.2022 | Cortuluá | - | Deportes Tolima | 0:1 | ||||
| 19. Ronde | 23.10.2022 | Deportes Tolima | - | Millonarios | 1:0 | ||||
| 20. Ronde | 29.10.2022 | Envigado FC | - | Deportes Tolima | 1:1 |
Colombia