| 1. Ronde | 10.07.2022 | La Equidad | - | Santa Fe | 2:2 | ||||
| 2. Ronde | 14.07.2022 | Águilas Doradas | - | Santa Fe | 2:2 | ||||
| 3. Ronde | 17.07.2022 | Santa Fe | - | Cortuluá | 1:0 |  |
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| 6. Ronde | 08.08.2022 | Deportivo Pereira | - | Santa Fe | 0:1 |  |
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| 7. Ronde | 14.08.2022 | Santa Fe | - | Deportes Tolima | 2:1 | ||||
| 8. Ronde | 21.08.2022 | Independiente Medellín | - | Santa Fe | 2:0 |  |
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| 9. Ronde | 27.08.2022 | Santa Fe | - | Patriotas FC | 2:1 | ||||
| 10. Ronde | 04.09.2022 | Millonarios | - | Santa Fe | 2:0 | ||||
| 12. Ronde | 17.09.2022 | Atlético Bucaramanga | - | Santa Fe | 2:1 | |
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| 14. Ronde | 25.09.2022 | Unión Magdalena | - | Santa Fe | 0:2 | |
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| 13. Ronde | 30.09.2022 | Santa Fe | - | Atlético Nacional | 1:1 | |
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| 18. Ronde | 17.10.2022 | Jaguares de Córdoba | - | Santa Fe | 2:1 | ||||
| 19. Ronde | 22.10.2022 | Santa Fe | - | Deportivo Cali | 1:0 | |
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| 20. Ronde | 30.10.2022 | Santa Fe | - | Once Caldas | 2:1 | |
Colombia