| 1. Ronde | 24.02.2025 | Los Angeles Galaxy | - | San Diego FC | 0:2 |  |
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| 2. Ronde | 02.03.2025 | San Diego FC | - | St. Louis City SC | 0:0 | |
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| 3. Ronde | 09.03.2025 | Real Salt Lake | - | San Diego FC | 1:3 | ||||
| 4. Ronde | 16.03.2025 | San Diego FC | - | Columbus Crew | 1:1 | ||||
| 6. Ronde | 30.03.2025 | San Diego FC | - | Los Angeles FC | 3:2 | ||||
| 7. Ronde | 06.04.2025 | San Diego FC | - | Seattle Sounders | 3:0 |  |
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| 8. Ronde | 13.04.2025 | Colorado Rapids | - | San Diego FC | 3:2 | ||||
| 9. Ronde | 20.04.2025 | Charlotte FC | - | San Diego FC | 3:0 | ||||
| 10. Ronde | 27.04.2025 | San Diego FC | - | Real Salt Lake | 1:3 | ||||
| 11. Ronde | 04.05.2025 | San Diego FC | - | FC Dallas | 5:0 | ||||
| 12. Ronde | 11.05.2025 | St. Louis City SC | - | San Diego FC | 1:2 | ||||
| 13. Ronde | 15.05.2025 | San Diego FC | - | Colorado Rapids | 2:0 | ||||
| 14. Ronde | 18.05.2025 | San Diego FC | - | Sporting Kansas City | 0:0 | |
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| 15. Ronde | 24.05.2025 | San Diego FC | - | Los Angeles Galaxy | 2:1 | ||||
| 16. Ronde | 29.05.2025 | Seattle Sounders | - | San Diego FC | 1:0 | ||||
| 17. Ronde | 01.06.2025 | San Diego FC | - | Austin FC | 2:0 | |
Panama