| 1. Ronde | 29.08.2021 | Lyon-La Duchère [B-jun] | - | Castelnau Le Crès FC [B-jun] | 4:3 |  |
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| 3. Ronde | 12.09.2021 | AS Saint-Priest [B-jun] | - | Lyon-La Duchère [B-jun] | 5:1 | ||||
| 5. Ronde | 25.09.2021 | Clermont Foot 63 [B-jun] | - | Lyon-La Duchère [B-jun] | 6:1 | ||||
| 7. Ronde | 10.10.2021 | AS Monaco [B-jun] | - | Lyon-La Duchère [B-jun] | 1:3 | ||||
| 9. Ronde | 24.10.2021 | Andrézieux-Bouthéon FC [B-jun] | - | Lyon-La Duchère [B-jun] | 3:4 | ||||
| 10. Ronde | 13.11.2021 | Lyon-La Duchère [B-jun] | - | Olympique Marseille [B-jun] | 0:3 | ||||
| 11. Ronde | 21.11.2021 | Olympique de Valence [B-jun] | - | Lyon-La Duchère [B-jun] | 6:1 | |
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| 12. Ronde | 28.11.2021 | Lyon-La Duchère [B-jun] | - | AC Ajaccio [B-jun] | 2:0 | ||||
| 13. Ronde | 04.12.2021 | Racing FC Toulon [B-jun] | - | Lyon-La Duchère [B-jun] | 0:2 | ||||
| 17. Ronde | 12.02.2022 | Lyon-La Duchère [B-jun] | - | Clermont Foot 63 [B-jun] | 2:3 | ||||
| 18. Ronde | 06.03.2022 | SC Air Bel [B-jun] | - | Lyon-La Duchère [B-jun] | 2:2 | ||||
| 21. Ronde | 27.03.2022 | Lyon-La Duchère [B-jun] | - | Andrézieux-Bouthéon FC [B-jun] | 2:0 | ||||
| 23. Ronde | 10.04.2022 | Lyon-La Duchère [B-jun] | - | Olympique de Valence [B-jun] | 5:3 |
Frankrijk