| 3. Ronde | 24.01.2022 | Santos Laguna | - | Club Necaxa | 1:4 | ||||
| 4. Ronde | 06.02.2022 | Club Necaxa | - | CF Pachuca | 1:3 | ||||
| 6. Ronde | 19.02.2022 | Club Tijuana | - | Club Necaxa | 1:1 |  |
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| 8. Ronde | 02.03.2022 | Mazatlán FC | - | Club Necaxa | 0:0 | ||||
| 11. Ronde | 20.03.2022 | Pumas UNAM | - | Club Necaxa | 1:3 | ||||
| 12. Ronde | 03.04.2022 | Club Necaxa | - | CF América | 0:1 | ||||
| 14. Ronde | 16.04.2022 | Club Necaxa | - | Atlético San Luis | 4:2 | ||||
| 15. Ronde | 20.04.2022 | Club Necaxa | - | UANL Tigres | 2:0 | |
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| 16. Ronde | 23.04.2022 | Puebla FC | - | Club Necaxa | 0:1 | ||||
| 17. Ronde | 30.04.2022 | Club Necaxa | - | Deportivo Guadalajara | 0:1 |
Mexico
Guatemala