| 6. Ronde | 16.10.2021 | Apollon Smyrnis | - | Asteras Tripolis | 0:1 |  |
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| 7. Ronde | 23.10.2021 | Asteras Tripolis | - | Panathinaikos | 2:1 | ||||
| 8. Ronde | 31.10.2021 | PAS Giannina | - | Asteras Tripolis | 1:1 | |
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| 9. Ronde | 07.11.2021 | Asteras Tripolis | - | Lamia | 0:1 | ||||
| 10. Ronde | 20.11.2021 | Ionikos Nikea | - | Asteras Tripolis | 1:1 | ||||
| 11. Ronde | 27.11.2021 | Asteras Tripolis | - | Atromitos | 6:2 | ||||
| 12. Ronde | 05.12.2021 | Aris Saloniki | - | Asteras Tripolis | 1:0 | ||||
| 13. Ronde | 11.12.2021 | Asteras Tripolis | - | AEK Athene | 0:0 | ||||
| 15. Ronde | 19.12.2021 | PAOK Saloniki | - | Asteras Tripolis | 3:2 | ||||
| 20. Ronde | 29.01.2022 | Panathinaikos | - | Asteras Tripolis | 0:1 | ||||
| 21. Ronde | 02.02.2022 | Asteras Tripolis | - | PAS Giannina | 2:0 | ||||
| 23. Ronde | 12.02.2022 | Asteras Tripolis | - | Ionikos Nikea | 2:3 | ||||
| 24. Ronde | 19.02.2022 | Atromitos | - | Asteras Tripolis | 2:0 | ||||
| 17. Ronde | 02.03.2022 | Olympiakos | - | Asteras Tripolis | 5:1 |
Griekenland