| 1. Ronde | 13.01.2021 | Municipal Grecia | - | Deportivo Saprissa | 0:0 | ||||
| 2. Ronde | 17.01.2021 | Deportivo Saprissa | - | Jicaral | 2:2 |  |
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| 4. Ronde | 26.01.2021 | Guadalupe | - | Deportivo Saprissa | 2:2 | ||||
| 3. Ronde | 28.01.2021 | Deportivo Saprissa | - | Sporting FC | 4:0 | |
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| 5. Ronde | 31.01.2021 | Deportivo Saprissa | - | CS Cartaginés | 4:1 | |
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| 11. Ronde | 04.03.2021 | Deportivo Saprissa | - | AD San Carlos | 1:1 | ||||
| 12. Ronde | 07.03.2021 | Deportivo Saprissa | - | Municipal Grecia | 1:2 | ||||
| 13. Ronde | 14.03.2021 | Jicaral | - | Deportivo Saprissa | 0:0 | |
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| 14. Ronde | 21.03.2021 | Sporting FC | - | Deportivo Saprissa | 1:0 | ||||
| 20. Ronde | 26.04.2021 | CS Herediano | - | Deportivo Saprissa | 2:2 | |
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| 21. Ronde | 03.05.2021 | Deportivo Saprissa | - | Santos de Guápiles | 3:1 | ||||
| 22. Ronde | 13.05.2021 | AD San Carlos | - | Deportivo Saprissa | 2:0 | |
Costa Rica