| 2. Ronde | 31.07.2021 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 0:3 | ||||
| 3. Ronde | 09.08.2021 | Deportivo Saprissa | - | CS Herediano | 2:3 | ||||
| 4. Ronde | 11.08.2021 | Guadalupe | - | Deportivo Saprissa | 1:1 | ||||
| 5. Ronde | 14.08.2021 | Deportivo Saprissa | - | Municipal Grecia | 1:0 |  |
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| 6. Ronde | 18.08.2021 | CS Cartaginés | - | Deportivo Saprissa | 1:0 | ||||
| 7. Ronde | 25.08.2021 | Deportivo Saprissa | - | Jicaral | 4:0 | ||||
| 9. Ronde | 08.09.2021 | Sporting FC | - | Deportivo Saprissa | 4:0 |  |
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| 10. Ronde | 13.09.2021 | AD San Carlos | - | Deportivo Saprissa | 1:0 | ||||
| 22. Ronde | 28.11.2021 | AD Guanacasteca | - | Deportivo Saprissa | 1:0 | |
Costa Rica