| 3. Ronde | 05.09.2021 | EA Guingamp [A-jun] | - | USSA Vertou [A-jun] | 2:0 | ||||
| 5. Ronde | 19.09.2021 | EA Guingamp [A-jun] | - | FC Nantes [A-jun] | 0:3 | ||||
| 9. Ronde | 17.10.2021 | EA Guingamp [A-jun] | - | US Concarneau [A-jun] | 0:0 | ||||
| 10. Ronde | 24.10.2021 | Stade Lavallois [A-jun] | - | EA Guingamp [A-jun] | 0:1 | ||||
| 11. Ronde | 14.11.2021 | EA Guingamp [A-jun] | - | Stade Rennais [A-jun] | 1:0 | ||||
| 15. Ronde | 16.01.2022 | USSA Vertou [A-jun] | - | EA Guingamp [A-jun] | 1:0 | ||||
| 17. Ronde | 20.03.2022 | EA Guingamp [A-jun] | - | US Avranches [A-jun] | 4:1 | ||||
| 18. Ronde | 27.03.2022 | US Concarneau [A-jun] | - | EA Guingamp [A-jun] | 0:4 |  |
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| 23. Ronde | 13.04.2022 | Stade Rennais [A-jun] | - | EA Guingamp [A-jun] | 1:2 | ||||
| 24. Ronde | 17.04.2022 | EA Guingamp [A-jun] | - | Stade Brestois 29 [A-jun] | 0:1 | ||||
| 25. Ronde | 01.05.2022 | EA Guingamp [A-jun] | - | Tours FC [A-jun] | 4:0 | ||||
| 26. Ronde | 15.05.2022 | Le Mans FC [A-jun] | - | EA Guingamp [A-jun] | 2:2 |
Frankrijk