| 1. Ronde | 01.08.2021 | Real Estelí FC | - | H&H Export Sébaco | 4:0 | ||||
| 2. Ronde | 10.08.2021 | UNAN Managua | - | H&H Export Sébaco | 0:2 | ||||
| 3. Ronde | 15.08.2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 6. Ronde | 03.09.2021 | ART Municipal Jalapa | - | H&H Export Sébaco | 0:2 | ||||
| 7. Ronde | 12.09.2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 | ||||
| 9. Ronde | 26.09.2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | ||||
| 10. Ronde | 02.10.2021 | H&H Export Sébaco | - | Real Estelí FC | 1:3 | ||||
| 12. Ronde | 16.10.2021 | Club Deportivo Ocotal | - | H&H Export Sébaco | 1:1 |  |
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| 13. Ronde | 21.10.2021 | Managua FC | - | H&H Export Sébaco | 1:2 | ||||
| 14. Ronde | 23.10.2021 | H&H Export Sébaco | - | Juventus Managua | 3:3 | ||||
| 15. Ronde | 31.10.2021 | CD Walter Ferretti | - | H&H Export Sébaco | 2:1 | ||||
| 16. Ronde | 04.11.2021 | H&H Export Sébaco | - | ART Municipal Jalapa | 3:0 | |
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| 17. Ronde | 17.11.2021 | H&H Export Sébaco | - | Diriangén FC | 1:1 | ||||
| 18. Ronde | 20.11.2021 | H&H Export Sébaco | - | Real Madriz | 2:3 |
Nicaragua