| 9. Ronde | 16.02.2022 | Pyramids FC | - | Ismaily | 1:0 | ||||
| 10. Ronde | 24.02.2022 | National Bank SC | - | Pyramids FC | 0:1 | ||||
| 8. Ronde | 08.03.2022 | Al Ahly SC | - | Pyramids FC | 3:0 | ||||
| 11. Ronde | 06.04.2022 | Pyramids FC | - | Zamalek | 2:3 | ||||
| 13. Ronde | 09.04.2022 | Pyramids FC | - | Ghazl Al Mehalla | 1:0 | ||||
| 17. Ronde | 01.05.2022 | El Gouna | - | Pyramids FC | 1:2 | ||||
| 14. Ronde | 06.05.2022 | Smouha Sporting Club | - | Pyramids FC | 0:2 |  |
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| 18. Ronde | 11.05.2022 | Misr lel-Maqasah SC | - | Pyramids FC | 0:2 | ||||
| 19. Ronde | 15.05.2022 | Pyramids FC | - | Pharco FC | 0:0 | ||||
| 20. Ronde | 22.05.2022 | Ittihad El Iskandary | - | Pyramids FC | 1:0 | ||||
| 23. Ronde | 29.06.2022 | Pyramids FC | - | ENPPI | 1:0 | ||||
| 25. Ronde | 16.07.2022 | Pyramids FC | - | Al Ahly SC | 2:0 | ||||
| 26. Ronde | 24.07.2022 | Ismaily | - | Pyramids FC | 0:4 | ||||
| 27. Ronde | 27.07.2022 | Pyramids FC | - | National Bank SC | 1:0 | |
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| 28. Ronde | 01.08.2022 | Zamalek | - | Pyramids FC | 3:0 | ||||
| 30. Ronde | 09.08.2022 | Ghazl Al Mehalla | - | Pyramids FC | 0:2 | ||||
| 31. Ronde | 19.08.2022 | Pyramids FC | - | Smouha Sporting Club | 5:1 | ||||
| 32. Ronde | 22.08.2022 | Future FC | - | Pyramids FC | 1:0 | |
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| 34. Ronde | 30.08.2022 | Pyramids FC | - | El Gouna | 1:3 |
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