| 2. Ronde | 11.09.2021 | De Graafschap [U21] | - | SBV Excelsior [U21] | 0:1 | ||||
| 3. Ronde | 18.09.2021 | Roda JC Kerkrade [U21] | - | De Graafschap [U21] | 3:3 |  |
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| 4. Ronde | 25.09.2021 | De Graafschap [U21] | - | FC Emmen [U21] | 1:1 | |
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| 7. Ronde | 23.10.2021 | De Graafschap [U21] | - | Alphense Boys [U21] | 2:1 | ||||
| 8. Ronde | 30.10.2021 | De Graafschap [U21] | - | Vitesse [U21] | 6:0 | |
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| 9. Ronde | 06.11.2021 | FC Emmen [U21] | - | De Graafschap [U21] | 1:2 | |
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| 13. Ronde | 12.02.2022 | Alphense Boys [U21] | - | De Graafschap [U21] | 1:3 |
Nederland