| 9. Ronde | 12.09.2021 | FC Sheriff | - | CS Petrocub | 2:0 | ||||
| 10. Ronde | 19.09.2021 | FC Zimbru | - | FC Sheriff | 1:1 |  |
|||
| 11. Ronde | 22.09.2021 | FC Sheriff | - | FC Floreşti | 4:0 |  |
|||
| 12. Ronde | 25.09.2021 | Dinamo-Auto | - | FC Sheriff | 0:7 | |
|||
| 13. Ronde | 02.10.2021 | FC Milsami | - | FC Sheriff | 0:1 | ||||
| 14. Ronde | 16.10.2021 | FC Sheriff | - | FC Sfîntul Gheorghe | 4:0 | ||||
| 18. Ronde | 20.11.2021 | FC Floreşti | - | FC Sheriff | 1:3 | |
|
||
| 19. Ronde | 28.11.2021 | FC Sheriff | - | Dinamo-Auto | 7:0 | ||||
| 3. Ronde | 11.12.2021 | FC Sheriff | - | FC Zimbru | 4:0 | ||||
| 6. Ronde | 01.03.2022 | FC Sheriff | - | FC Milsami | 1:0 | ||||
| 7. Ronde | 05.03.2022 | FC Sheriff | - | FC Sfîntul Gheorghe | 2:0 | ||||
| 24. Ronde | 16.04.2022 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 26. Ronde | 29.04.2022 | Dinamo-Auto | - | FC Sheriff | 0:3 | ||||
| 27. Ronde | 07.05.2022 | FC Milsami | - | FC Sheriff | 1:1 |
Noord-Macedonië