| 5. Ronde | 06.02.2022 | FAS | - | Santa Tecla FC | 2:0 | ||||
| 6. Ronde | 09.02.2022 | Municipal Limeño | - | FAS | 1:1 | ||||
| 7. Ronde | 13.02.2022 | FAS | - | Atlético Marte | 3:0 | ||||
| 8. Ronde | 20.02.2022 | Isidro Metapán | - | FAS | 1:1 |  |
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| 9. Ronde | 23.02.2022 | FAS | - | AD Chalatenango | 1:3 | |
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| 10. Ronde | 27.02.2022 | Luis Ángel Firpo | - | FAS | 2:3 |  |
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| 4. Ronde | 03.03.2022 | Alianza | - | FAS | 1:1 | ||||
| 14. Ronde | 23.03.2022 | FAS | - | Jocoro FC | 2:1 | ||||
| 15. Ronde | 03.04.2022 | FAS | - | Alianza | 1:3 | |
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| 16. Ronde | 10.04.2022 | Santa Tecla FC | - | FAS | 1:1 | ||||
| 17. Ronde | 13.04.2022 | FAS | - | Municipal Limeño | 1:1 | ||||
| 18. Ronde | 17.04.2022 | Atlético Marte | - | FAS | 1:1 | |
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| 22. Ronde | 07.05.2022 | Platense Zacatecoluca | - | FAS | 1:2 | |
El Salvador