| 4. Ronde | 18.09.2010 | Racing | - | River Plate | 2:0 | ||||
| 5. Ronde | 25.09.2010 | River Plate | - | Tacuarembó | 2:0 | ||||
| 6. Ronde | 03.10.2010 | Danubio | - | River Plate | 1:2 | ||||
| 7. Ronde | 09.10.2010 | River Plate | - | Peñarol | 2:1 | ||||
| 8. Ronde | 16.10.2010 | CA Cerro | - | River Plate | 0:0 | ||||
| 9. Ronde | 24.10.2010 | River Plate | - | Liverpool | 1:2 | ||||
| 10. Ronde | 30.10.2010 | Nacional | - | River Plate | 6:1 | ||||
| 11. Ronde | 07.11.2010 | Miramar Misiones | - | River Plate | 1:1 |  |
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| 12. Ronde | 14.11.2010 | River Plate | - | El Tanque Sisley | 1:2 | ||||
| 13. Ronde | 21.11.2010 | Montevideo Wanderers | - | River Plate | 1:2 |  |
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| 14. Ronde | 27.11.2010 | River Plate | - | Fénix | 1:2 | ||||
| 15. Ronde | 05.12.2010 | Bella Vista | - | River Plate | 1:0 |
Uruguay