| 20. Ronde | 05.02.2022 | Grasshopper Club Zürich | - | FC Zürich | 1:3 | ||||
| 21. Ronde | 12.02.2022 | FC Lausanne-Sport | - | Grasshopper Club Zürich | 0:2 |  |
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| 22. Ronde | 20.02.2022 | Grasshopper Club Zürich | - | BSC Young Boys | 2:2 | |
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| 23. Ronde | 27.02.2022 | FC St. Gallen | - | Grasshopper Club Zürich | 2:0 | |
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| 24. Ronde | 03.03.2022 | Grasshopper Club Zürich | - | FC Lugano | 1:2 | ||||
| 26. Ronde | 13.03.2022 | FC Luzern | - | Grasshopper Club Zürich | 1:0 | ||||
| 29. Ronde | 09.04.2022 | Grasshopper Club Zürich | - | FC Luzern | 2:2 | ||||
| 30. Ronde | 16.04.2022 | Servette FC | - | Grasshopper Club Zürich | 0:1 | |
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| 32. Ronde | 30.04.2022 | FC Lugano | - | Grasshopper Club Zürich | 1:1 | ||||
| 34. Ronde | 12.05.2022 | FC Basel 1893 | - | Grasshopper Club Zürich | 1:1 | ||||
| 35. Ronde | 19.05.2022 | Grasshopper Club Zürich | - | FC St. Gallen | 3:2 | ||||
| 36. Ronde | 22.05.2022 | BSC Young Boys | - | Grasshopper Club Zürich | 3:0 | |
Portugal