| 8. Ronde | 28.08.2021 | FC Bălţi | - | FC Sheriff | 0:2 | ||||
| 9. Ronde | 12.09.2021 | FC Sheriff | - | CS Petrocub | 2:0 | ||||
| 10. Ronde | 19.09.2021 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 11. Ronde | 22.09.2021 | FC Sheriff | - | FC Floreşti | 4:0 |  |
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| 13. Ronde | 02.10.2021 | FC Milsami | - | FC Sheriff | 0:1 | ||||
| 14. Ronde | 16.10.2021 | FC Sheriff | - | FC Sfîntul Gheorghe | 4:0 | |
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| 15. Ronde | 23.10.2021 | FC Sheriff | - | FC Bălţi | 2:0 |  |
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| 18. Ronde | 20.11.2021 | FC Floreşti | - | FC Sheriff | 1:3 | ||||
| 19. Ronde | 28.11.2021 | FC Sheriff | - | Dinamo-Auto | 7:0 | ||||
| 2. Ronde | 02.12.2021 | CS Petrocub | - | FC Sheriff | 0:0 | ||||
| 3. Ronde | 11.12.2021 | FC Sheriff | - | FC Zimbru | 4:0 | ||||
| 20. Ronde | 13.03.2022 | FC Sheriff | - | FC Milsami | 0:1 | |
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| 21. Ronde | 19.03.2022 | FC Sfîntul Gheorghe | - | FC Sheriff | 0:3 | |
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| 22. Ronde | 03.04.2022 | FC Bălţi | - | FC Sheriff | 0:3 | ||||
| 23. Ronde | 08.04.2022 | FC Sheriff | - | CS Petrocub | 1:0 | ||||
| 24. Ronde | 16.04.2022 | FC Zimbru | - | FC Sheriff | 1:1 | ||||
| 26. Ronde | 29.04.2022 | Dinamo-Auto | - | FC Sheriff | 0:3 | |
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| 28. Ronde | 14.05.2022 | FC Sheriff | - | FC Sfîntul Gheorghe | 2:0 |
Brazilië