| 6. Ronde | 18.02.2021 | UANL Tigres | - | Cruz Azul | 0:2 | ||||
| 8. Ronde | 28.02.2021 | Club León | - | Cruz Azul | 0:1 |  |
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| 9. Ronde | 04.03.2021 | Cruz Azul | - | Mazatlán FC | 1:0 | ||||
| 10. Ronde | 08.03.2021 | Pumas UNAM | - | Cruz Azul | 0:1 | ||||
| 11. Ronde | 14.03.2021 | Cruz Azul | - | CF Monterrey | 1:0 | ||||
| 12. Ronde | 21.03.2021 | Cruz Azul | - | Atlas Guadalajara | 3:2 | |
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| 13. Ronde | 03.04.2021 | FC Juárez | - | Cruz Azul | 0:1 | ||||
| 15. Ronde | 18.04.2021 | CF América | - | Cruz Azul | 1:1 | ||||
| 16. Ronde | 25.04.2021 | Cruz Azul | - | Atlético San Luis | 3:2 | ||||
| 17. Ronde | 02.05.2021 | Cruz Azul | - | Club Tijuana | 1:1 |
Ecuador