| 1. Ronde | 01.08.2021 | CD Walter Ferretti | - | Real Madriz | 4:1 |  |
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| 2. Ronde | 08.08.2021 | CD Walter Ferretti | - | Club Deportivo Ocotal | 4:0 | ||||
| 4. Ronde | 22.08.2021 | ART Municipal Jalapa | - | CD Walter Ferretti | 2:0 | ||||
| 6. Ronde | 02.09.2021 | CD Walter Ferretti | - | Juventus Managua | 2:0 | ||||
| 7. Ronde | 12.09.2021 | H&H Export Sébaco | - | CD Walter Ferretti | 4:8 | ||||
| 3. Ronde | 23.09.2021 | CD Walter Ferretti | - | Diriangén FC | 2:3 | ||||
| 9. Ronde | 27.09.2021 | CD Walter Ferretti | - | Managua FC | 0:0 |  |
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| 10. Ronde | 02.10.2021 | Real Madriz | - | CD Walter Ferretti | 3:1 | ||||
| 8. Ronde | 07.10.2021 | Real Estelí FC | - | CD Walter Ferretti | 1:1 | ||||
| 11. Ronde | 10.10.2021 | Club Deportivo Ocotal | - | CD Walter Ferretti | 3:0 | ||||
| 12. Ronde | 17.10.2021 | Diriangén FC | - | CD Walter Ferretti | 4:2 | ||||
| 13. Ronde | 21.10.2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 5:0 | ||||
| 14. Ronde | 25.10.2021 | UNAN Managua | - | CD Walter Ferretti | 0:1 | ||||
| 16. Ronde | 04.11.2021 | Juventus Managua | - | CD Walter Ferretti | 2:2 | ||||
| 17. Ronde | 19.11.2021 | CD Walter Ferretti | - | Real Estelí FC | 4:0 |
Nicaragua