| 1. Ronde | 14.08.2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 | ||||
| 2. Ronde | 21.08.2021 | Royal Excel Mouscron | - | Lommel SK | 0:1 | ||||
| 3. Ronde | 29.08.2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 |  |
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| 7. Ronde | 02.10.2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 10. Ronde | 29.10.2021 | Excelsior Virton | - | Royal Excel Mouscron | 0:2 | ||||
| 11. Ronde | 06.11.2021 | Royal Excel Mouscron | - | SK Deinze | 2:0 | ||||
| 12. Ronde | 19.11.2021 | Waasland-Beveren | - | Royal Excel Mouscron | 0:2 | ||||
| 13. Ronde | 28.11.2021 | Royal Excel Mouscron | - | Lierse Kempenzonen | 2:1 | ||||
| 15. Ronde | 11.12.2021 | Royal Excel Mouscron | - | Lommel SK | 2:1 | ||||
| 16. Ronde | 18.12.2021 | SK Deinze | - | Royal Excel Mouscron | 2:2 | ||||
| 17. Ronde | 23.01.2022 | Royal Excel Mouscron | - | Lierse Kempenzonen | 0:0 | ||||
| 21. Ronde | 20.02.2022 | Royal Excel Mouscron | - | Excelsior Virton | 2:1 | ||||
| 23. Ronde | 06.03.2022 | Royal Excel Mouscron | - | RWD Molenbeek | 0:1 | ||||
| 26. Ronde | 03.04.2022 | Excelsior Virton | - | Royal Excel Mouscron | 2:0 | ||||
| 28. Ronde | 17.04.2022 | Waasland-Beveren | - | Royal Excel Mouscron | 2:0 |
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