| 1. Ronde | 01.08.2021 | Once Municipal | - | CD Águila | 2:2 | ||||
| 6. Ronde | 25.08.2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 | ||||
| 9. Ronde | 16.09.2021 | Isidro Metapán | - | Once Municipal | 0:1 | ||||
| 10. Ronde | 19.09.2021 | Once Municipal | - | Atlético Marte | 0:0 | ||||
| 11. Ronde | 26.09.2021 | Santa Tecla FC | - | Once Municipal | 0:1 |  |
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| 12. Ronde | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 | ||||
| 14. Ronde | 09.10.2021 | Municipal Limeño | - | Once Municipal | 1:1 | ||||
| 19. Ronde | 14.11.2021 | FAS | - | Once Municipal | 3:2 | ||||
| 20. Ronde | 18.11.2021 | Once Municipal | - | Isidro Metapán | 1:1 | ||||
| 22. Ronde | 27.11.2021 | Once Municipal | - | Santa Tecla FC | 4:3 |
El Salvador