| 5. Ronde | 14.08.2021 | Sporting FC | - | CS Cartaginés | 4:1 | ||||
| 6. Ronde | 18.08.2021 | CS Cartaginés | - | Deportivo Saprissa | 1:0 | ||||
| 7. Ronde | 25.08.2021 | CS Cartaginés | - | Guadalupe | 0:1 |  |
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| 8. Ronde | 29.08.2021 | CS Herediano | - | CS Cartaginés | 2:0 | ||||
| 15. Ronde | 13.10.2021 | AD San Carlos | - | CS Cartaginés | 0:1 | |
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| 16. Ronde | 19.10.2021 | CS Cartaginés | - | Sporting FC | 1:0 | ||||
| 17. Ronde | 25.10.2021 | Deportivo Saprissa | - | CS Cartaginés | 1:1 | ||||
| 18. Ronde | 27.10.2021 | Guadalupe | - | CS Cartaginés | 1:1 | ||||
| 19. Ronde | 31.10.2021 | CS Cartaginés | - | CS Herediano | 0:1 |  |
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| 21. Ronde | 25.11.2021 | Santos de Guápiles | - | CS Cartaginés | 1:2 | ||||
| 22. Ronde | 28.11.2021 | CS Cartaginés | - | Jicaral | 4:0 |
Costa Rica