| 2. Ronde | 30.01.2022 | Atlético Huila | - | Barranquilla FC | 0:0 |  |
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| 3. Ronde | 06.02.2022 | Barranquilla FC | - | Real Cartagena | 0:2 | |
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| 4. Ronde | 13.02.2022 | Real Santander | - | Barranquilla FC | 2:3 |  |
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| 5. Ronde | 19.02.2022 | Barranquilla FC | - | Atlético FC | 1:0 | ||||
| 7. Ronde | 06.03.2022 | Barranquilla FC | - | Bogotá FC | 2:4 | ||||
| 10. Ronde | 26.03.2022 | Deportes Quindío | - | Barranquilla FC | 2:1 | ||||
| 11. Ronde | 03.04.2022 | Barranquilla FC | - | Boyacá Chicó | 2:2 | ||||
| 9. Ronde | 06.04.2022 | Barranquilla FC | - | Llaneros FC | 1:2 | ||||
| 12. Ronde | 11.04.2022 | Boca Juniors de Cali | - | Barranquilla FC | 0:0 | ||||
| 13. Ronde | 16.04.2022 | Barranquilla FC | - | Valledupar FC | 1:1 | |
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| 14. Ronde | 25.04.2022 | Tigres FC | - | Barranquilla FC | 2:0 | ||||
| 15. Ronde | 04.05.2022 | Barranquilla FC | - | Fortaleza FC | 0:1 |
Colombia