| 1. Ronde | 28.07.2021 | Municipal Grecia | - | CS Cartaginés | 4:0 | ||||
| 4. Ronde | 11.08.2021 | CS Cartaginés | - | AD San Carlos | 5:1 | ||||
| 5. Ronde | 14.08.2021 | Sporting FC | - | CS Cartaginés | 4:1 | ||||
| 6. Ronde | 18.08.2021 | CS Cartaginés | - | Deportivo Saprissa | 1:0 | ||||
| 9. Ronde | 08.09.2021 | CS Cartaginés | - | Municipal Pérez Zeledón | 2:1 | ||||
| 17. Ronde | 25.10.2021 | Deportivo Saprissa | - | CS Cartaginés | 1:1 | ||||
| 18. Ronde | 27.10.2021 | Guadalupe | - | CS Cartaginés | 1:1 | ||||
| 21. Ronde | 25.11.2021 | Santos de Guápiles | - | CS Cartaginés | 1:2 |  |
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| 22. Ronde | 28.11.2021 | CS Cartaginés | - | Jicaral | 4:0 |
Costa Rica