| 1. Ronde | 28.07.2021 | Real Cartagena | - | Valledupar FC | 2:2 | ||||
| 2. Ronde | 31.07.2021 | Valledupar FC | - | Leones FC | 1:1 | ||||
| 4. Ronde | 15.08.2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 5. Ronde | 26.08.2021 | Barranquilla FC | - | Valledupar FC | 2:1 | ||||
| 6. Ronde | 30.08.2021 | Valledupar FC | - | Bogotá FC | 0:2 | ||||
| 7. Ronde | 06.09.2021 | Atlético FC | - | Valledupar FC | 3:2 |  |
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| 8. Ronde | 11.09.2021 | Valledupar FC | - | Orsomarso SC | 1:2 | ||||
| 10. Ronde | 28.09.2021 | Boyacá Chicó | - | Valledupar FC | 2:0 | ||||
| 11. Ronde | 03.10.2021 | Valledupar FC | - | Fortaleza FC | 1:1 | ||||
| 12. Ronde | 09.10.2021 | Real Santander | - | Valledupar FC | 1:1 | ||||
| 13. Ronde | 19.10.2021 | Valledupar FC | - | Cortuluá | 1:2 | ||||
| 15. Ronde | 30.10.2021 | Valledupar FC | - | Boca Juniors de Cali | 2:1 | |
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Colombia