| 1. Ronde | 17.01.2021 | Deportes Quindío | - | Valledupar FC | 1:2 |  |
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| 2. Ronde | 23.01.2021 | Valledupar FC | - | Orsomarso SC | 3:4 | ||||
| 3. Ronde | 31.01.2021 | Boca Juniors de Cali | - | Valledupar FC | 1:2 | ||||
| 4. Ronde | 09.02.2021 | Valledupar FC | - | Real Cartagena | 2:0 |  |
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| 5. Ronde | 12.02.2021 | Real Santander | - | Valledupar FC | 0:1 | ||||
| 6. Ronde | 15.02.2021 | Valledupar FC | - | Bogotá FC | 6:0 | |
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| 7. Ronde | 23.02.2021 | Fortaleza FC | - | Valledupar FC | 3:2 | ||||
| 8. Ronde | 27.02.2021 | Valledupar FC | - | Leones FC | 0:1 | ||||
| 9. Ronde | 04.03.2021 | Atlético Huila | - | Valledupar FC | 3:1 | ||||
| 10. Ronde | 07.03.2021 | Valledupar FC | - | Cortuluá | 1:2 | ||||
| 11. Ronde | 13.03.2021 | Atlético FC | - | Valledupar FC | 0:1 | |
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| 13. Ronde | 27.03.2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 14. Ronde | 05.04.2021 | Llaneros FC | - | Valledupar FC | 2:1 | ||||
| 15. Ronde | 09.04.2021 | Valledupar FC | - | Unión Magdalena | 1:2 |
Colombia